Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases

Yang Liu, Haiming Xu, Suchao Chen, Xianfeng Chen, Zhenguo Zhang, Zhihong Zhu, Xueying Qin, Landian Hu, Jun Zhu, Guo-Ping Zhao and Xiangyin Kong

PLOS Genetics, 2011, vol. 7, issue 3, 1-16

Abstract: Genome-wide interaction-based association (GWIBA) analysis has the potential to identify novel susceptibility loci. These interaction effects could be missed with the prevailing approaches in genome-wide association studies (GWAS). However, no convincing loci have been discovered exclusively from GWIBA methods, and the intensive computation involved is a major barrier for application. Here, we developed a fast, multi-thread/parallel program named “pair-wise interaction-based association mapping” (PIAM) for exhaustive two-locus searches. With this program, we performed a complete GWIBA analysis on seven diseases with stringent control for false positives, and we validated the results for three of these diseases. We identified one pair-wise interaction between a previously identified locus, C1orf106, and one new locus, TEC, that was specific for Crohn's disease, with a Bonferroni corrected P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1001338

DOI: 10.1371/journal.pgen.1001338

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