Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

Christina M Lill, Johannes T Roehr, Matthew B McQueen, Fotini K Kavvoura, Sachin Bagade, Brit-Maren M Schjeide, Leif M Schjeide, Esther Meissner, Ute Zauft, Nicole C Allen, Tian Liu, Marcel Schilling, Kari J Anderson, Gary Beecham, Daniela Berg, Joanna M Biernacka, Alexis Brice, Anita L DeStefano, Chuong B Do, Nicholas Eriksson, Stewart A Factor, Matthew J Farrer, Tatiana Foroud, Thomas Gasser, Taye Hamza, John A Hardy, Peter Heutink, Erin M Hill-Burns, Christine Klein, Jeanne C Latourelle, Demetrius M Maraganore, Eden R Martin, Maria Martinez, Richard H Myers, Michael A Nalls, Nathan Pankratz, Haydeh Payami, Wataru Satake, William K Scott, Manu Sharma, Andrew B Singleton, Kari Stefansson, Tatsushi Toda, Joyce Y Tung, Jeffery Vance, Nick W Wood, Cyrus P Zabetian, 23andMe, The Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium, The International Parkinson's Disease Genomics Consortium (ipdgc), The Parkinson's Disease GWAS Consortium, The Wellcome Trust Case Control Consortium 2 (wtccc2), Peter Young, Rudolph E Tanzi, Muin J Khoury, Frauke Zipp, Hans Lehrach, John P A Ioannidis and Lars Bertram

PLOS Genetics, 2012, vol. 8, issue 3, 1-10

Abstract: More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of ∼27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Meta-analyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1002548

DOI: 10.1371/journal.pgen.1002548

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