Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

Cade, Brian E; Chen, Han; Stilp, Adrienne M; Louie, Tin; Ancoli-Israel, Sonia; Arens, Raanan; Barfield, Richard; Below, Jennifer E; Cai, Jianwen; Conomos, Matthew P; Evans, Daniel S; Frazier-Wood, Alexis C; Gharib, Sina A; Gleason, Kevin J; Gottlieb, Daniel J; Hillman, David R; Johnson, W Craig; Lederer, David J; Lee, Jiwon; Loredo, Jose S; Mei, Hao; Mukherjee, Sutapa; Patel, Sanjay R; Post, Wendy S; Purcell, Shaun M; Ramos, Alberto R; Reid, Kathryn J; Rice, Ken; Shah, Neomi A; Sofer, Tamar; Taylor, Kent D; Thornton, Timothy A; Wang, Heming; Yaffe, Kristine; Zee, Phyllis C; Hanis, Craig L; Palmer, Lyle J; Rotter, Jerome I; Stone, Katie L; Tranah, Gregory J; Wilson, James G; Sunyaev, Shamil R; Laurie, Cathy C; Zhu, Xiaofeng; Saxena, Richa; Lin, Xihong; Redline, Susan

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

Brian E Cade, Han Chen, Adrienne M Stilp, Tin Louie, Sonia Ancoli-Israel, Raanan Arens, Richard Barfield, Jennifer E Below, Jianwen Cai, Matthew P Conomos, Daniel S Evans, Alexis C Frazier-Wood, Sina A Gharib, Kevin J Gleason, Daniel J Gottlieb, David R Hillman, W Craig Johnson, David J Lederer, Jiwon Lee, Jose S Loredo, Hao Mei, Sutapa Mukherjee, Sanjay R Patel, Wendy S Post, Shaun M Purcell, Alberto R Ramos, Kathryn J Reid, Ken Rice, Neomi A Shah, Tamar Sofer, Kent D Taylor, Timothy A Thornton, Heming Wang, Kristine Yaffe, Phyllis C Zee, Craig L Hanis, Lyle J Palmer, Jerome I Rotter, Katie L Stone, Gregory J Tranah, James G Wilson, Shamil R Sunyaev, Cathy C Laurie, Xiaofeng Zhu, Richa Saxena, Xihong Lin and Susan Redline

PLOS Genetics, 2019, vol. 15, issue 4, 1-31

Abstract: Sleep disordered breathing (SDB)-related overnight hypoxemia is associated with cardiometabolic disease and other comorbidities. Understanding the genetic bases for variations in nocturnal hypoxemia may help understand mechanisms influencing oxygenation and SDB-related mortality. We conducted genome-wide association tests across 10 cohorts and 4 populations to identify genetic variants associated with three correlated measures of overnight oxyhemoglobin saturation: average and minimum oxyhemoglobin saturation during sleep and the percent of sleep with oxyhemoglobin saturation under 90%. The discovery sample consisted of 8,326 individuals. Variants with p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pgen00:1007739

DOI: 10.1371/journal.pgen.1007739

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