PLOS Pathogens

2005 - 2026

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Volume 22, issue 10, 2026

Why does rotavirus vaccine effectiveness vary around the globe? pp. 1-9

Sarah Woodyear, Nabila Nawar Binti and Sarah L Caddy

Vaccination accelerates the race of influenza virus against collective immunity pp. 1-21

Igor M Rouzine

Volume 22, issue 9, 2026

Serine protease inhibitor from Trichinella spiralis ameliorates diet-induced obesity and adipose tissue inflammation through TIM-3-dependent macrophage reprogramming pp. 1-24

Mingwei Tong, Ge Liu, Guidong Ren, Wangxuan Zhang, Yuyu Qiao, Xiaodan Yang, Weiping Fan, Hui Yang and Yong Yang

Analysis of host and viral nascent and steady-state RNA levels in a human neuronal model of herpes simplex virus 1 infection pp. 1-37

Claire H Birkenheuer, Terri G Edwards, David C Bloom and Joel D Baines

Evidence for multiple prion conformers in natural scrapie isolates pp. 1-20

Morikazu Imamura, Kohtaro Miyazawa, Hiroyuki Okada, Minako Ohno, Hiromi Iguchi, Yuichi Matsuura, Yoshifumi Iwamaru, Hanae Takatsuki, Tsuyoshi Mori, Jiyan Ma and Ryuichiro Atarashi

The insect- and plant-associated lifestyles of Pseudomonas protegens CHA0 are preserved following serial passage through insect larvae pp. 1-33

Maria Zwyssig, Jana Schneider, Gijs Selten, Christoph Keel, Monika Maurhofer and Ronnie de Jonge

Transposon-insertion sequencing reveals NlpD as a vulnerability in intracellular survival and pathogenesis of Salmonella 4,[5],12:i:- pp. 1-35

Mengping He, Jinju Cai, Huihui Wu, Tianqi Xu, Haijie Zhang, Zhiqiang Wang and Yuan Liu

Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial and fungal superinfection susceptibility pp. 1-28

Kehinde Adebayo Babatunde, Mtakai Ngara, Paola Martinez Murillo, Bibin Subramanian, Alex Hopke, Simone Lucchesi, Maria Novedrati, Giorgio Montesi, Francesco Santoro, Michael Hagemann-Jensen, Rickard Sandberg, Luis Filgueira, Michael Walch, Daniel Irimia and Pierre-Yves Mantel

PRMT3 restricts porcine epidemic diarrhea virus replication by disrupting the interaction between VAPA and the viral nucleocapsid protein pp. 1-28

He-Yong Wu, Shu-Yu Zhong, Ao-Si Qi, Zi-Ru Wang, Qiu-Se Tu, Feng Li, Rui Wu, Jing-Yao Wang, Fan Song, Tian-Yi Zhang, Ting Li, Qing-Chun Yu, Hong-Ming Yuan, Dong-Mei Lv, Hong-Sheng Ouyang, Xi-Liang Du, Da-Xin Pang and Zi-Cong Xie

Volume 22, issue 8, 2026

Cyclic di-GMP directly reprograms the multidrug resistance machinery via UspG-mediated sequestration of RamR in Klebsiella pp. 1-23

Xiaoxiao Liu, Mingfang Wang, Yikai Fu, Xiangjie Zhu, Miao Du, Yao Wen, Yiwen Liao, Yunhu Zhao, Yinyue Deng and Bing Gu

Structural and functional characterization of a conserved cryptic epitope on SARS-CoV-2 spike S2 subunit pp. 1-28

Ling Zhou, Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Andrew P Horton, Sophie R Shoemaker, Elizabeth C Gardner, John M Powers, Daniel R Boutz, Michael L Mallory, Connor M Mullins, Nicole V Johnson, Alexandra L Tse, Albert Wang, Kamyab Javanmardi, Lily E Adams, Jonathan Schisler, Susan Marqusee, Kartik Chandran, Ralph S Baric, Jimmy D Gollihar and Jason S McLellan

Does Toxoplasma gondii infection have a causal impact on human psychopathology? A Mendelian randomization analysis pp. 1-20

Jinyong Pang, Matthew J Valente, Kami Kim and Xiaoming Liu

TRPV4-mediated calcium influx contributes temperature-dependent SARS-CoV-2 replication pp. 1-20

Moe Kobayashi, Hatsumi Abe, Hikaruko Sugihara, Nene Kobayashi, Seira Omori, Yasuhiro Yamada and Takeshi Ichinohe

Volume 22, issue 7, 2026

Environmental drivers of low vaccine responsiveness in a lab-to-wild rodent model pp. 1-23

Simon A Babayan, Saudamini Venkatesan, Jessica L Hall, Ewan W Smith, Amy R Sweeny and Amy B Pedersen

Volume 22, issue 5, 2026

LuxS/AI-2 regulates phoP/phoQ by a non-canonical mechanism to enhance acid stress survival in Salmonella Typhimurium pp. 1-28

Anmol Singh, Abhilash Vijay Nair, Shashanka Aroli, Suman Das, Subhrajit Karmakar, Raju S Rajmani, Santanu Mukherjee, Umesh Varshney and Dipshikha Chakravortty

Volume 22, issue 3, 2026

Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex pp. 1-27

Yushu He, Yang Wang, Xiaoying He, Qingbo Lv, Isabelle Vallee, Pascal Boireau, Jing Ding and Xiaolei Liu

Volume 21, issue 9, 2025

Activation of PD-1/PD-L1 immune checkpoint by Zika virus pp. 1-22

Chenxi Wang, Yubin Xie, Weixin Li, Chon Phin Ong, Hao Ding, Shuofeng Yuan, Gong Cheng, Dong-Yan Jin and Zi-Wei Ye

The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome pp. 1-8

Phuti Choshi, Sarah Pedretti, Tafadzwa Chimbetete, Rama Gangula, Muki Shey, Cari Stek, Rachel P J Lai, Robert Wilkinson, Graeme Meintjes, Elizabeth Phillips and Jonny Peter

Volume 21, issue 6, 2025

Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis pp. 1-18

Riya Ghosh, Garima Joshi, Nishith M Shrimali, Kanchan Bhardwaj, Tsewang Chorol, Tashi Thinlas, Parvaiz A Koul, Josef T Prchal and Prasenjit Guchhait

The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii pp. 1-24

Jeanette M Critchlow, Joseph S Rocchio, Melanie C McKell, Courtney J Campbell, Juan P Barraza, Evan S Krystofiak, Erin R Green, Tae Akizuki, Walter J Chazin, Michael S VanNieuwenhze, Timothy L Stemmler, David P Giedroc and Eric P Skaar

Volume 21, issue 4, 2025

The molecular basis for DNA-binding by competence T4P is distinct in a representative Gram-positive and Gram-negative species pp. 1-19

Nicholas D Christman and Ankur B Dalia

Volume 21, issue 3, 2025

Selection and characterization of a broadly neutralizing class of HCV anti-E2 VH1-69 antibodies pp. 1-23

Andreas Soerensen, Filip Popovic, Christina Holmboe Olesen, Blanca Lopez Mendez, Brian Lohse, Zhaochun Chen, Patrizia Farci, Robert H Purcell, Harvey J Alter, Lea Klingenberg Barfod, Jens Bukh and Jannick Prentoe

Volume 20, issue 12, 2024

Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression pp. 1-31

Marloes Grobben, Margreet Bakker, Angela I Schriek, Liesbeth JJ Levels, Jeffrey C Umotoy, Khadija Tejjani, Mariëlle J van Breemen, Ryan N Lin, Steven W de Taeye, Gabriel Ozorowski, Neeltje A Kootstra, Andrew B Ward, Stephen J Kent, P Mark Hogarth, Bruce D Wines, Rogier W Sanders, Amy W Chung and Marit J van Gils

TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages pp. 1-22

Moe Kobayashi, Nene Kobayashi, Kyoka Deguchi, Seira Omori, Minami Nagai, Ryutaro Fukui, Isaiah Song, Shinji Fukuda, Kensuke Miyake and Takeshi Ichinohe

Volume 20, issue 10, 2024

High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic pp. 1-21

Moira Kelly, Christina A Cuomo, Wouter Beukema, Salvador Carranza, Jesse Erens, Marleen Foubert, Zhimin Li, Stefan Lötters, Vanessa Schulz, Sebastian Steinfartz, Sarah Van Praet, Michael Veith, Frank Pasmans and An Martel

Volume 20, issue 9, 2024

Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays pp. 1-24

Ankit Srivastava, Qinlu Wang, Christina D Orrù, Manel Fernandez, Yaroslau Compta, Bernardino Ghetti, Gianluigi Zanusso, Wen-Quan Zou, Byron Caughey and Catherine A A Beauchemin

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal pp. 1-32

William J Cisneros, Shimaa H A Soliman, Miriam Walter, Lacy M Simons, Daphne Cornish, Simone De Fabritiis, Ariel W Halle, Eun-Young Kim, Steven M Wolinsky, Ramon Lorenzo-Redondo, Ali Shilatifard and Judd F Hultquist

Volume 20, issue 8, 2024

Data alchemy, from lab to insight: Transforming in vivo experiments into data science gold pp. 1-7

Troy J Kieran, Taronna R Maines and Jessica A Belser

Volume 20, issue 7, 2024

Influenza A viral burst size from thousands of infected single cells using droplet quantitative PCR (dqPCR) pp. 1-23

Geoffrey K Zath, Mallory M Thomas, Emma K Loveday, Dimitri A Bikos, Steven Sanche, Ruian Ke, Christopher B Brooke and Connie B Chang

Volume 20, issue 6, 2024

Zinc-finger (ZiF) fold secreted effectors form a functionally diverse family across lineages of the blast fungus Magnaporthe oryzae pp. 1-25

Juan Carlos De la Concepcion, Thorsten Langner, Koki Fujisaki, Xia Yan, Vincent Were, Anson Ho Ching Lam, Indira Saado, Helen J Brabham, Joe Win, Kentaro Yoshida, Nicholas J Talbot, Ryohei Terauchi, Sophien Kamoun and Mark J Banfield

IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission pp. 1-27

Arun Prakash, Florence Fenner, Biswajit Shit, Tiina S Salminen, Katy M Monteith, Imroze Khan and Pedro F Vale

CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan pp. 1-28

Linda Heilig, Fariha Natasha, Nora Trinks, Vishukumar Aimanianda, Sarah Sze Wah Wong, Thierry Fontaine, Ulrich Terpitz, Lea Strobel, François Le Mauff, Donald C Sheppard, Sascha Schäuble, Oliver Kurzai, Kerstin Hünniger, Esther Weiss, Mario Vargas, P Lynne Howell, Gianni Panagiotou, Sebastian Wurster, Hermann Einsele and Juergen Loeffler

Volume 20, issue 5, 2024

Meta-analysis of Epstein-Barr virus genomes in Southern Chinese identifies genetic variants and high risk viral lineage associated with nasopharyngeal carcinoma pp. 1-19

Ka Wo Wong, Kwai Fung Hui, Ki Pui Lam, Dora Lai-wan Kwong, Maria Li Lung, Wanling Yang and Alan K S Chiang

Volume 20, issue 4, 2024

Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics pp. 1-28

Rebecca M Johnson, Isaac J Stopard, Helen M Byrne, Philip M Armstrong, Douglas E Brackney and Ben Lambert

Predicting the presence of infectious virus from PCR data: A meta-analysis of SARS-CoV-2 in non-human primates pp. 1-39

Celine E Snedden and James O Lloyd-Smith

Dynamic changes of Bacterial Microbiomes in Oropharynx during Infection and Recovery of COVID-19 Omicron Variant pp. 1-26

Guangying Cui, Ying Sun, Yawen Zou, Ranran Sun, Yanxia Gao, Xiaorui Liu, Yongjian Zhou, Donghua Zhang, Xueqing Wang, Yonghong Li, Liwen Liu, Guizhen Zhang, Benchen Rao, Zujiang Yu and Zhigang Ren

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context pp. 1-26

Iris Mair, Jonathan Fenn, Andrew Wolfenden, Ann E Lowe, Alex Bennett, Andrew Muir, Jacob Thompson, Olive Dieumerci, Larisa Logunova, Susanne Shultz, Janette E Bradley and Kathryn J Else

Lineage frequency time series reveal elevated levels of genetic drift in SARS-CoV-2 transmission in England pp. 1-37

QinQin Yu, Joao A Ascensao, Takashi Okada, The COVID-19 Genomics UK (COG-UK) Consortium, Olivia Boyd, Erik Volz and Oskar Hallatschek

Beyond the VSG layer: Exploring the role of intrinsic disorder in the invariant surface glycoproteins of African trypanosomes pp. 1-23

Hagen Sülzen, Alexander N Volkov, Rob Geens, Farnaz Zahedifard, Benoit Stijlemans, Martin Zoltner, Stefan Magez, Yann G-J Sterckx and Sebastian Zoll

Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review pp. 1-19

Naomi M Fuller, Christopher F McQuaid, Martin J Harker, Chathika K Weerasuriya, Timothy D McHugh and Gwenan M Knight

Small RNA SmsR1 modulates acidogenicity and cariogenic virulence by affecting protein acetylation in Streptococcus mutans pp. 1-24

Jing Li, Qizhao Ma, Jun Huang, Yaqi Liu, Jing Zhou, Shuxing Yu, Qiong Zhang, Yongwang Lin, Lingyun Wang, Jing Zou and Yuqing Li

Volume 20, issue 1, 2024

Trained immunity in recurrent Staphylococcus aureus infection promotes bacterial persistence pp. 1-22

Xiao-Qi Lin, Zhen-Zhen Liu, Cheng-Kai Zhou, Liang Zhang, Yu Gao, Xue-Yue Luo, Jian-Gang Zhang, Wei Chen and Yong-Jun Yang

Volume 19, issue 12, 2023

Regulation of human neutrophil IL-1β secretion induced by Escherichia coli O157:H7 responsible for hemolytic uremic syndrome pp. 1-24

Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Alexia Vereertbrugghen, Douglas Vera Aguilar, Paolo Nahuel Rubatto Birri, Manuela Pizzano, María Victoria Ramos, Federico Fuentes, Lucas Saposnik, Agostina Cernutto, Juliana Cassataro, Carolina Cristina Jancic, Jeremías Gaston Galletti, Marina Sandra Palermo and Analía Silvina Trevani

Volume 19, issue 11, 2023

Open Science at PLOS Pathogens pp. 1-6

Lauren Cadwallader, Kasturi Haldar, Rebecca Kirk, Neil A Mabbott and Michael H Malim

Volume 19, issue 10, 2023

Prevention of zoonotic spillover: From relying on response to reducing the risk at source pp. 1-8

Authored by the members of the One Health High-Level Expert Panel (ohhlep), Wanda Markotter, Thomas C Mettenleiter, Wiku B Adisasmito, Salama Almuhairi, Casey Barton Behravesh, Pépé Bilivogui, Salome A Bukachi, Natalia Casas, Natalia Cediel Becerra, Dominique F Charron, Abhishek Chaudhary, Janice R Ciacci Zanella, Andrew A Cunningham, Osman Dar, Nitish Debnath, Baptiste Dungu, Elmoubasher Farag, George F Gao, David T S Hayman, Margaret Khaitsa, Marion P G Koopmans, Catherine Machalaba, John S Mackenzie, Serge Morand, Vyacheslav Smolenskiy and Lei Zhou

The Aspergillus fumigatus UPR is variably activated across nutrient and host environments and is critical for the establishment of corneal infection pp. 1-32

Manali M Kamath, Jorge D Lightfoot, Emily M Adams, Ryan M Kiser, Becca L Wells and Kevin K Fuller

Volume 19, issue 9, 2023

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo pp. 1-23

Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramaugé Parra, Etienne Kornobis, Eliette Bonnefoy and Xavier Montagutelli

Volume 19, issue 8, 2023

Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias pp. 1-24

Helen R Fryer, Tanya Golubchik, Matthew Hall, Christophe Fraser, Robert Hinch, Luca Ferretti, Laura Thomson, Anel Nurtay, Lorenzo Pellis, Thomas House, George MacIntyre-Cockett, Amy Trebes, David Buck, Paolo Piazza, Angie Green, Lorne J Lonie, Darren Smith, Matthew Bashton, Matthew Crown, Andrew Nelson, Clare M McCann, Mohammed Adnan Tariq, Claire J Elstob, Rui Nunes Dos Santos, Zack Richards, Xin Xhang, Joseph Hawley, Mark R Lee, Priscilla Carrillo-Barragan, Isobel Chapman, Sarah Harthern-Flint, The COVID-19 Genomics UK (COG-UK) Consortium, David Bonsall and Katrina A Lythgoe

Volume 19, issue 7, 2023

Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire pp. 1-23

Allister Irvine, Darrin McKenzie, Ciaran J McCoy, Robert L J Graham, Ciaren Graham, Sharon A Huws, Louise E Atkinson and Angela Mousley

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression pp. 1-25

Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Renata B Filler, Scott B Biering, Sylvia A Sarnik, Sonam Patel, Bridget L Menasche, Susan R Compton, Silvana Konermann, Patrick D Hsu, Robert C Orchard, Qin Yan and Craig B Wilen

Volume 19, issue 6, 2023

Advancing the central role of non-model biorepositories in predictive modeling of emerging pathogens pp. 1-8

Jocelyn P Colella, Marlon E Cobos, Irene Salinas, Joseph A Cook and The PICANTE Consortium

Neutralization profiles of HIV-1 viruses from the VRC01 Antibody Mediated Prevention (AMP) trials pp. 1-17

Nonhlanhla N Mkhize, Anna E J Yssel, Haajira Kaldine, Rebecca T van Dorsten, Amanda S Woodward Davis, Nicolas Beaume, David Matten, Bronwen Lambson, Tandile Modise, Prudence Kgagudi, Talita York, Dylan H Westfall, Elena E Giorgi, Bette Korber, Colin Anthony, Rutendo E Mapengo, Valerie Bekker, Elizabeth Domin, Amanda Eaton, Wenjie Deng, Allan DeCamp, Yunda Huang, Peter B Gilbert, Asanda Gwashu-Nyangiwe, Ruwayhida Thebus, Nonkululeko Ndabambi, Dieter Mielke, Nyaradzo Mgodi, Shelly Karuna, Srilatha Edupuganti, Michael S Seaman, Lawrence Corey, Myron S Cohen, John Hural, M Juliana McElrath, James I Mullins, David Montefiori, Penny L Moore, Carolyn Williamson and Lynn Morris

Volume 19, issue 5, 2023

α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification pp. 1-29

Manisha Naskar, Viraj P Parekh, Mathew A Abraham, Zehra Alibasic, Min Jung Kim, Gyeongseo Suk, Joo Hwan Noh, Kwan Young Ko, Joonha Lee, Chungho Kim, Hana Yoon, Soman N Abraham and Hae Woong Choi

Volume 19, issue 1, 2023

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence pp. 1-29

Shishir Singh, Mateo Murillo-León, Niklas Sebastian Endres, Ailan Farid Arenas Soto, Jorge Enrique Gómez-Marín, Florence Melbert, Thirumala-Devi Kanneganti, Masahiro Yamamoto, Claudia Campos, Jonathan Charles Howard, Gregory Alan Taylor and Tobias Steinfeldt

Making the best of research investment in pathogens control through biocontrol. How is research correlated with agricultural microbial biological control product availability? pp. 1-8

Florența-Elena Helepciuc and Arpad Todor

Race and ethnicity: Risk factors for fungal infections? pp. 1-22

Jeffrey D Jenks, Chioma Inyang Aneke, Mohanad M Al-Obaidi, Matthias Egger, Lorena Garcia, Tommi Gaines, Martin Hoenigl and George R Thompson