The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome

Phuti Choshi, Sarah Pedretti, Tafadzwa Chimbetete, Rama Gangula, Muki Shey, Cari Stek, Rachel P J Lai, Robert Wilkinson, Graeme Meintjes, Elizabeth Phillips and Jonny Peter

PLOS Pathogens, 2025, vol. 21, issue 9, 1-8

Abstract: Genetic associations within the human leukocyte antigen (HLA) gene complex and linked genes in TB-IRIS outcomes remains population specific and not well understood. Here, we conducted a study including well characterised HIV-TB coinfected patients with (n = 86) and without (n = 124) TB-IRIS from the randomized, double-blind, prophylactic prednisone trial (PredART study) with HLA, ERAP and KIR genotyping data. We confirmed the association of TB-IRIS with lower CD4 counts pre-ART initiation. We identified nine classical class I and II HLA alleles protective against TB-IRIS, while four alleles were linked to increased risk. Associations ranged from strongly protective (HLA-DQB1*05:01, OR: 0.07, 95%CI: 0.02-0.28, Pc

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:ppat00:1013497

DOI: 10.1371/journal.ppat.1013497

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