A Review and Meta-Analysis of Prostate Cancer Utilities

Karen E. Bremner, Christopher A. K. Y. Chong, George Tomlinson, Shabbir M. H. Alibhai and Murray D. Krahn
Additional contact information
Karen E. Bremner: Toronto General Research Institute University Health Network, kbremner@uhnresearch.ca
Christopher A. K. Y. Chong: Department of Medicine, University of Toronto, Canada
George Tomlinson: Toronto General Research Institute University Health Network, Department of Medicine, University of Toronto, Canada, Department of Health Policy, Management, and Evaluation, University of Toronto, Canada, Department of Biostatistics, University of Toronto, Canada
Shabbir M. H. Alibhai: Toronto General Research Institute University Health Network, Department of Medicine, University of Toronto, Canada, Department of Health Policy, Management, and Evaluation, University of Toronto, Canada
Murray D. Krahn: Toronto General Research Institute University Health Network, Department of Medicine, University of Toronto, Canada, Department of Health Policy, Management, and Evaluation, University of Toronto, Canada, Department of Pharmacy, University of Toronto, Canada

Medical Decision Making, 2007, vol. 27, issue 3, 288-298

Abstract: Background. Health-related quality of life is a key issue in prostate cancer (PC) management. The authors summarized published utilities for common health-related quality of life outcomes of PC and determined how methodological factors affect them. Methods. In their systematic review, the authors identified 23 articles in English, providing 173 unique utilities for PC health states, each obtained from 2 to 422 respondents. Data were pooled using linear mixed-effects modeling with utilities clustered within the study, weighted by the number of respondents divided by the variance of each utility. Results. In the base model, the estimated utility of the reference case (scenario of a metastatic PC patient with severe sexual symptoms, rated by non-PC patients using time tradeoff) was 0.76. Disease stage, symptom type and severity, source of utility, and scaling method were associated with utility differences of 0.10 to 0.32 (P

Keywords: Key words: prostate cancer; utility assessment; preferences; quality of life; meta-analysis. (Med Decis Making 2007; 27:288—298) (search for similar items in EconPapers)
Date: 2007
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Persistent link: https://EconPapers.repec.org/RePEc:sae:medema:v:27:y:2007:i:3:p:288-298

DOI: 10.1177/0272989X07300604

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