Feasibility and Reliability of the Annual Profile Method for Deriving QALYs for Short-Term Health Conditions

Mathieu F. Janssen, Erwin Birnie and Gouke Bonsel
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Mathieu F. Janssen: Department of Social Medicine-Public Health Epidemiology, Academic Medical Center, Amsterdam, the Netherlands, m.f.janssen@amc.uva.nl
Erwin Birnie: Department of Social Medicine-Public Health Epidemiology, Academic Medical Center, Amsterdam, the Netherlands, Institute of Health Policy and Management, Erasmus Medical Center, Rotterdam, the Netherlands
Gouke Bonsel: Department of Social Medicine-Public Health Epidemiology, Academic Medical Center, Amsterdam, the Netherlands, Institute of Health Policy and Management, Erasmus Medical Center, Rotterdam, the Netherlands

Medical Decision Making, 2008, vol. 28, issue 4, 500-510

Abstract: Introduction . When health varies over time, the standard quality-adjusted life year model operates under the assumptions of time utility independence within each health state and additive independence between health states. These assumptions can be relaxed by an integral assessment of disease severity over time. The authors present the annual profile method (APM), which values health profiles on a 1-year base, and test the APM for feasibility, consistency, and test-retest reliability. Methods . A population panel, general practitioners, medical advisers, and a panel of the Dutch Consumers Association valued vignettes for 46 disease stages using the visual analog scale (VAS) and time tradeoff (TTO) methods. Vignettes contained disease-specific information, a generic description (EQ-6D5L), a description of the disease course over time, and a visual representation of the disease. Feasibility was tested by missing and inconsistent responses. Consistency between and within panels was tested with a generalizability study, analysis of variance, and standard correlation coefficients. Test-retest reliability was tested with a generalizability study and intra-class correlation coefficients. Results . Missing and inconsistent responses were

Keywords: Key words: quality-adjusted life years; methodology; utility measurement; reliability; health status. (Med Decis Making 2008; 28:500—510) (search for similar items in EconPapers)
Date: 2008
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Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:sae:medema:v:28:y:2008:i:4:p:500-510

DOI: 10.1177/0272989X07312711

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