An Economic Evaluation of a Laboratory Monitoring Program for Renin-Angiotensin System Agents

David H. Smith, Marsha A. Raebel, K. Arnold Chan, Eric S. Johnson, Amanda F. Petrik, Jessica R. Weiss, Xiuhai Yang and Adrianne Feldstein

Medical Decision Making, 2011, vol. 31, issue 2, 315-324

Abstract: Background . The efficiency of patient safety interventions is not well studied, especially laboratory monitoring for drug therapy. More than one-third of preventable adverse drug events are associated with inadequate monitoring. Current knowledge of decreasing adverse drug events through expanded monitoring programs is lacking. Design . The authors focused on a laboratory monitoring program (above usual practice) of renin-angiotensin system (RAS) agents to prevent adverse events of hyperkalemia and acute renal failure. They used a probabilistic decision model to estimate cost savings and cost effectiveness (at $30,000 and $10,000 per quality-adjusted life-year (QALY)). Costs included the monitoring program, and offsets from reduced care in 3 populations (overall, chronic kidney disease [CKD], and diabetes). Main results . Adverse events were most common in those with CKD. Intervening on all new users or the subset with diabetes was almost never expected to be cost saving (probability

Keywords: cost-effectiveness analysis; health economics; comparative effectiveness; evidence synthesis (search for similar items in EconPapers)
Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:sae:medema:v:31:y:2011:i:2:p:315-324

DOI: 10.1177/0272989X10379918

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