Health-Related Quality of Life in HIV-Infected and At-Risk Women

Brandon Aden, Bohdan Nosyk, Eve Wittenberg and Bruce R. Schackman

Medical Decision Making, 2014, vol. 34, issue 6, 800-808

Abstract: Purpose. To assess the impact of illicit drug use and chronic hepatitis C virus (HCV) on health-related quality of life (HRQoL) in women with HIV or at risk for HIV infection. Methods. Cross-sectional analysis of data from the Women’s Interagency Health Study (WIHS) of women with HIV ( n = 2508) and at high risk of HIV infection ( n = 889) in the US. A Short-Form-6D (SF-6D) HRQoL measure derived from the Medical Outcomes Study–HIV (MOS-HIV) questionnaire, HIV infection status, CD4 cell count (a measure of immune status), antiretroviral treatment, current illicit drug use (heroin and/or cocaine), and HCV status were assessed at a recent study visit. We developed multivariate linear regression models adjusting for age, race/ethnicity, education, and testing for interactions. Results. HIV-infected women with ≤200 CD4 cells/µL had lower mean HRQoL scores (0.69) than either HIV-infected women with >200 CD4 cells/µL (0.78) or HIV-uninfected women (0.80) ( P 200 CD4 cells/µL had a significantly greater reduction in HRQoL associated with illicit drug use (−0.063) and chronic HCV (−0.036) than women with ≤200 CD4 cells/µL (−0.017, −0.005 respectively). Conclusions. Poorly controlled HIV, illicit drug use, and chronic HCV are associated with lower HRQoL. Illicit drug use and chronic HCV have greater HRQoL impacts for HIV-infected women with well-controlled HIV versus those with poorly controlled HIV, which may affect clinical and policy priorities.

Keywords: HIV; health-related quality of life; opiate dependence; health utility; illicit drug use; hepatitis C virus (search for similar items in EconPapers)
Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:sae:medema:v:34:y:2014:i:6:p:800-808

DOI: 10.1177/0272989X13507340

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