Mapping a Patient-Reported Functional Outcome Measure to a Utility Measure for Comparative Effectiveness and Economic Evaluations in Older Adults with Low Back Pain

Sean D. Rundell, Brian W. Bresnahan, Patrick J. Heagerty, Bryan A. Comstock, Janna L. Friedly, Jeffrey G. Jarvik and Sean D. Sullivan

Medical Decision Making, 2014, vol. 34, issue 7, 873-883

Abstract: Background. Linking patient-reported back pain outcomes with health utility measures is valuable for informing economic evaluations. Methods. We used the Back pain Outcomes using Longitudinal Data (BOLD) registry to assess back pain and quality-of-life measures. The BOLD registry includes participants ≥65 years from 3 health systems. We used multiple baseline outcome measures: Roland-Morris Disability Questionnaire (RMDQ), Euroqol-5D (EQ-5D), and back and leg pain numerical rating scales (NRS). To develop and validate a model, we used a standard split-sample method and a novel multisite validation approach. We applied linear regression to map RMDQ to EQ-5D, adjusting for age, sex, pain numerical rating scores, and nonlinear transformations of outcome measures. We computed R 2 , root mean squared error, and mean absolute error (MAE) for purposes of model selection. The final model included EQ-5D as the dependent variable with independent variables of age, RMDQ, and back NRS. We used this model to predict EQ-5D scores in validation samples. Results. In total, 5224 participants had both baseline RMDQ and EQ-5D. Mean age was 74 years (65% female). Negative correlations (–0.72) were observed at baseline for RMDQ and EQ-5D. The selected model from all developmental samples had R 2 >0.41 and MAE

Keywords: low back pain; older adults; health economic evaluations; Roland-Morris Disability Questionnaire; EQ-5D (search for similar items in EconPapers)
Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:sae:medema:v:34:y:2014:i:7:p:873-883

DOI: 10.1177/0272989X14533995

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