Association between Exposure to Statin Choice and Adherence to Statins: An Observational Cohort Study

Kathryn A. Martinez, Victor M. Montori, Fatima Rodriguez, Larisa G. Tereshchenko, Jeffrey D. Kovach, Christopher Boyer, Heather McKee Hurwitz and Michael B. Rothberg
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Kathryn A. Martinez: Cleveland Clinic Center for Value-Based Care Research, Cleveland, OH, USA
Victor M. Montori: Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota, USA
Fatima Rodriguez: Division of Cardiovascular Medicine, the Cardiovascular Institute, and the Center for Digital Health, Stanford University School of Medicine, Stanford, CA, USA
Larisa G. Tereshchenko: Cleveland Clinic, Lerner Research Institute, Department of Quantitative Health Sciences, Cleveland, OH, USA
Jeffrey D. Kovach: Cleveland Clinic, Lerner Research Institute, Department of Quantitative Health Sciences, Cleveland, OH, USA
Christopher Boyer: Cleveland Clinic, Lerner Research Institute, Department of Quantitative Health Sciences, Cleveland, OH, USA
Heather McKee Hurwitz: Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
Michael B. Rothberg: Cleveland Clinic Center for Value-Based Care Research, Cleveland, OH, USA

Medical Decision Making, 2025, vol. 45, issue 7, 884-891

Abstract: Background Statin Choice is a shared decision-making encounter tool embedded in the electronic health record. Objective To describe the association between the use of Statin Choice, statin prescriptions by clinicians, prescription fills (primary adherence), and statin adherence at 12 mo (secondary adherence). Design Observational cohort study at the Cleveland Clinic Health System. Subjects Statin-naïve adults aged 40 to 75 y with a 10-y atherosclerotic cardiovascular disease (ASCVD) risk of ≥5% and a primary care appointment between January 2020 and July 2021. Main Measures The primary exposure was the use of Statin Choice during a clinical encounter. We measured whether the use of Statin Choice was associated with statin prescriptions. We measured statin adherence based on pharmacy fill data at 60 d (primary adherence) and 12 mo (secondary adherence). We used mixed-effects logistic regression to estimate the adjusted odds of statin prescriptions and adherence at the 3 time points by the use of Statin Choice. Key Results Among 17,001 statin-naïve patients, 13% viewed Statin Choice and 7% were prescribed a statin. The median ASCVD risk was 10%. Patients who were shown Statin Choice had 9.04 higher odds of being prescribed a statin compared with patients not shown Statin Choice (95% confidence interval [CI]: 7.86–10.4). Among patients prescribed a statin, the use of Statin Choice was associated with 5.75 higher odds of primary adherence compared with usual care (95% CI: 4.22–7.83). At 12 mo, Statin Choice use was significantly associated with adherence in the unadjusted analysis (OR: 1.58; 95% CI: 1.05–2.08) but was not significant after adjustment for patient factors. Patients shown Statin Choice had an average of 12 mg/dL reduction in low-density lipoprotein cholesterol at 12 mo (95% CI: −16 mg/dL, −10) compared with those not shown Statin Choice. Conclusion In this observational study, Statin Choice use was strongly associated with statin prescription and fills and weakly associated with adherence to statins for up to 1 y. A randomized trial is needed to confirm causality. Highlights Statin Choice is an electronic health record–embedded shared decision-making encounter tool available for free in many health care systems. Small randomized controlled trials have found modest associations between the use of Statin Choice and statin adherence using patient-reported data. In our large study using pharmacy fill data, clinician use of Statin Choice during a medical encounter was associated with significantly greater patient adherence with statins up to 1 y later. Exposure to Statin Choice was associated with a significant reduction in low-density lipoprotein cholesterol over 1 y.

Keywords: adherence; decision aids; risk communication; shared decision making; statins (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:sae:medema:v:45:y:2025:i:7:p:884-891

DOI: 10.1177/0272989X251346508

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