Computer Simulation to Study Inflammatory Response

Gary An and Irene Anne Lee
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Gary An: Cook County Hospital
Irene Anne Lee: 114 West Lupita Road, Santa Fe, NM 87505-4718, USA; telephone +1 505-820-7524; fax +1 505-820-7537;lee@elf.org.

Simulation & Gaming, 2001, vol. 32, issue 3, 344-361

Abstract: Systemic inflammatory response syndrome and its progression to multi-organ dysfunction syndrome represent a major challenge in the field of trauma and critical care medicine. This disease state is a product of disorders of the body’s natural response to injury. Attempts to treat this at a molecular level using information from basic science research have been unsuccessful, even detrimental. It is possible that this is due to a failure to account for the nonlinear, complex nature of the inflammatory response in formulating treatment regimes. It is proposed that agent-based computer simulation may be a way to characterize the dynamics of the inflammatory response. This article presents an abstract model of a generic tissue system. Modeling the inflammatory response as a nonlinear complex system may produce simulations that will shed light on the complex nature of the inflammatory response. In the future, more sophisticated simulations may provide a testing framework for designing and evaluating treatment regimes.

Keywords: agent-based modeling; complex systems; computer simulation; critical care medicine; inflammation; medical simulation; nonlinear; pharmacology; sepsis; shock; trauma (search for similar items in EconPapers)
Date: 2001
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Persistent link: https://EconPapers.repec.org/RePEc:sae:simgam:v:32:y:2001:i:3:p:344-361

DOI: 10.1177/104687810103200305

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