Estimating the Productivity Burden of Pediatric Pneumococcal Disease in Thailand

Thanpisit Ounsirithupsakul, Piyameth Dilokthornsakul (), Khachen Kongpakwattana, Zanfina Ademi, Danny Liew and Nathorn Chaiyakunapruk ()
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Thanpisit Ounsirithupsakul: Chulalongkorn University
Piyameth Dilokthornsakul: Naresuan University
Khachen Kongpakwattana: Monash University Malaysia
Zanfina Ademi: Monash University
Danny Liew: Monash University
Nathorn Chaiyakunapruk: University of Utah

Applied Health Economics and Health Policy, 2020, vol. 18, issue 4, No 12, 579-587

Abstract: Abstract Background Pneumococcal diseases were estimated to cause 1.6 million deaths annually worldwide in 2008, with approximately half of these occurring in children aged under 5 years. The consequences and deaths adversely impact individuals’ and caregivers’ work productivity. Objectives This study aimed to quantify the potential lifetime productivity loss due to pneumococcal diseases among the pediatric population in Thailand using productivity-adjusted life years (PALYs). Methods A decision analytic model was used to estimate the burden of pneumococcal diseases among the current Thai population aged 0–5 years and followed up until aged 99 years or death. Base-case analysis compared years of life and PALYs lost to pneumococcal diseases. Scenario analyses investigated the benefits of prevention with pneumococcal conjugated vaccine 13 (PCV 13). All health outcomes were discounted at 3% per annum. Results The base-case analysis estimated that 453,401 years of life and 457,598 PALYs would be lost to pneumococcal diseases, equating to a loss of US$5586 (95% CI 3338–10,302) million. Vaccination with PCV13 at birth was estimated to save 82,609 years of life and 93,759 PALYs, which equated to US$1144 (95% CI 367–2591) million in economic benefits. The incidence of pneumonia in those aged 0–4 years, vaccine efficacy, and the assumed period of protection were key determinants of the health economic outputs. Conclusions The disease and financial burden of pneumococcal diseases in Thailand is significant, but a large proportion of this is potentially preventable with vaccination.

Date: 2020
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DOI: 10.1007/s40258-020-00553-0

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