Productivity Loss and Indirect Costs for Patients Newly Diagnosed with Early- versus Late-Stage Cancer in the USA: A Large-Scale Observational Research Study

Ze Cong (), Oth Tran, James Nelson, Monica Silver and Karen Chung
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Ze Cong: GRAIL, LLC, a subsidiary of Illumina, Inc.
Oth Tran: Previously IBM Watson Health
James Nelson: IBM Watson Health
Monica Silver: IBM Watson Health
Karen Chung: GRAIL, LLC, a subsidiary of Illumina, Inc.

Applied Health Economics and Health Policy, 2022, vol. 20, issue 6, No 6, 845-856

Abstract: Abstract Background The total economic burden of cancer reflects direct and indirect costs, including productivity loss due to employment change, absenteeism, and presenteeism of patients and caregivers. Objective This study estimated the magnitude of employment decrease, work absence (WA), short-term disability (STD), long-term disability (LTD), and associated indirect costs among employees newly diagnosed with metastatic versus non-metastatic cancer in the USA. Methods IBM® MarketScan® Commercial Claims and Encounters and Health and Productivity Management databases were used to identify employees aged 18–64 years and newly diagnosed with any cancer from 2009 to 2019. Proportions of patients with employment decrease, WA, STD, and LTD claims, and number of days missing from work were summarized by metastatic status during the first 12 months after diagnosis and the entire follow-up period. Subgroup analyses were conducted by age (

Date: 2022
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DOI: 10.1007/s40258-022-00753-w

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