Measurement of Health-Related Quality of Life from Conception to Postpartum Using the EQ-5D-5L Among a National Sample of US Pregnant and Postpartum Adults

Annette K. Regan (), Pallavi Aytha Swathi, Marcianna Nosek and Ning Yan Gu
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Annette K. Regan: University of San Francisco
Pallavi Aytha Swathi: University of Colorado
Marcianna Nosek: University of San Francisco
Ning Yan Gu: University of San Francisco

Applied Health Economics and Health Policy, 2023, vol. 21, issue 3, No 14, 523-532

Abstract: Abstract Background During pregnancy, physiological changes occur from conception to birth. We assessed the health-related quality of life (HRQoL) throughout pregnancy and postpartum using the EQ-5D-5L. Methods Between May and July 2021 (wave 1) and December 2021 and April 2022 (wave 2), we conducted a series of cross-sectional, national online surveys of 5250 pregnant and postpartum United States (US) adults. The survey included the EQ-5D-5L, EQ visual analog scale (EQ VAS), items measuring respondents’ sociodemographic and health information, last menstrual period, estimated date of delivery, and date of pregnancy end (if postpartum). We examined monthly EQ-5D-5L items, utility values, and EQ VAS scores during pregnancy and postpartum. We used quantile regression adjusted for calendar month of last menstrual period to estimate changes in HRQoL at different time points of pregnancy and postpartum. Results There was a steady increase in the frequency of respondents reporting health-related problems and a decline in EQ-5D-5L utility values from early pregnancy until the ninth month of pregnancy (β = − 0.21; standard error [SE] 0.02; P

Date: 2023
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DOI: 10.1007/s40258-023-00798-5

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