Different Frameworks, Similar Results? Head-to-Head Comparison of the Generic Preference-Based Health-Outcome Measures CS-Base and EQ-5D-5L

Xin Zhang, Karin M. Vermeulen and Paul F. M. Krabbe ()
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Xin Zhang: University Medical Center Groningen
Karin M. Vermeulen: University Medical Center Groningen
Paul F. M. Krabbe: University Medical Center Groningen

Applied Health Economics and Health Policy, 2024, vol. 22, issue 2, No 9, 227-242

Abstract: Abstract Objective We compared two generic, preference-based health-outcome measures: the novel patient-centered Château-Santé Base (CS-Base), entailing a multi-attribute preference response framework, and the widely used EQ-5D-5L, regarding effects of different measurement frameworks and different descriptive systems. Methods We conducted a cross-sectional study using a random sample of patients (3019 reached, 1988 included) in the USA with various health conditions. The CS-Base (12 attributes, each with four levels), EQ-5D-5L and the 5D-4L (an ad hoc, multi-attribute preference response-based measure that includes five attributes similar to the EQ-5D-5L, but with four levels) were used as health-outcome measures. We compared the proportions of problems reported on health attributes, statistical robustness and face validity of coefficients, attribute importance, differentiation between health states based on health-state values obtained with these measures, and user experience. Results All the CS-Base and 5D-4L coefficients had logical orders and significant differences from the reference level (p

Date: 2024
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DOI: 10.1007/s40258-023-00837-1

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