Bayesian optimal design for $$2 \times 2$$ 2 × 2 binary crossover trials using copula

Satya Prakash Singh () and Deepak Prajapati ()
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Satya Prakash Singh: Indian Institute of Technology Kanpur
Deepak Prajapati: Decision Sciences Area Indian Institute of Management Lucknow

Computational Statistics, 2025, vol. 40, issue 9, No 1, 4875-4900

Abstract: Abstract In this article we have considered a $$2\times 2$$ 2 × 2 binary crossover trial. Two main difficulties on designing such trial are: (i) the association of observations measured on the same experimental unit over different time periods; and (ii) the dependency of design selection criterion on the unknown model parameters. Here we present a copula based approach to address (i). Further, a Bayesian approach is adopted to address (ii). Equivalence theorem is provided to verify the optimality of numerically obtained Bayesian design. The proposed methodology is supplemented by thorough numerical studies. Moreover, it is shown that the proposed optimal designs are more efficient than that of based on the generalized estimating equations approach.

Keywords: Bayesian design; Copula; Crossover trials; Efficiency; Locally optimal design (search for similar items in EconPapers)
Date: 2025
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DOI: 10.1007/s00180-024-01574-2

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