Health-Related Quality of Life in Chronic HCV-Infected Patients Switching to Pegylated-Interferon-Free Regimens (ANRS CO20 CUPIC Cohort Study and SIRIUS Trial)

Maria Patrizia Carrieri, Camelia Protopopescu (), Zobair Younossi, Antoine Vilotitch, Hélène Fontaine, Ventzislava Petrov-Sanchez, Fabienne Marcellin, Fabrice Carrat, Christophe Hézode and Marc Bourlière
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Maria Patrizia Carrieri: Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale
Zobair Younossi: Inova Fairfax Hospital
Antoine Vilotitch: Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale
Hélène Fontaine: INSERM, U1016, Hôpital Cochin
Ventzislava Petrov-Sanchez: ANRS (France Recherche Nord and Sud Sida-HIV Hépatites FRENSH)
Fabienne Marcellin: Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale
Fabrice Carrat: Sorbonne Universities, UPMC University of Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136)
Christophe Hézode: Hôpital Henri Mondor, AP-HP, University of Paris-Est, INSERM, U955
Marc Bourlière: Hôpital Saint Joseph

The Patient: Patient-Centered Outcomes Research, 2017, vol. 10, issue 5, No 9, 605-614

Abstract: Abstract Objective We aimed to compare health-related quality of life (HRQL) during and after hepatitis C virus (HCV) treatment in patients receiving pegylated-interferon (PEG-IFN)-containing therapy (including boceprevir or telaprevir—ANRS CO20 CUPIC cohort) who subsequently switched to PEG-IFN-free regimens (sofosbuvir + ledipasvir with or without ribavirin [RBV]—SIRIUS trial). Methods Two analyses were performed. The first compared physical (PCS) and mental (MCS) HRQL (MOS SF-12) scores during treatment between CUPIC and SIRIUS. The second compared PCS and MCS scores after treatment end between CUPIC and SIRIUS. The analyses used linear regression mixed models adjusted for pre-treatment HRQL scores, gender, and age at each visit. Results Among patients enrolled successively in both studies, 43 (corresponding to 212 HRQL assessments) and 43 (82 HRQL assessments) were eligible for the ‘during’ and ‘post’ treatment analyses, respectively. In the ‘during-treatment’ analysis, we found significantly higher PCS and MCS values during PEG-IFN-free treatment than for PEG-IFN-containing treatment. In the ‘post-treatment’ analysis, results showed significantly higher MCS values after PEG-IFN-free treatment than after PEG-IFN-containing treatment. No significant difference was found for PCS in the post-treatment analysis. Conclusions These results highlight an improvement in both physical and mental HRQL during HCV treatment, but no major improvement in physical HRQL after treatment end, when comparing PEG-IFN-free regimens with PEG-IFN-containing regimens. This suggests that in the PEG-IFN-free regimens era, screening and comprehensive care of comorbidities and residual somatic symptoms during treatment, and especially after HCV clearance, are still needed to improve patient outcomes.

Keywords: Sustained Virologic Response; Physical Component Summary; Mental Component Summary; Mental Component Summary Score; Telaprevir (search for similar items in EconPapers)
Date: 2017
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DOI: 10.1007/s40271-017-0232-1

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