EQ-5D-5L is More Responsive than EQ-5D-3L to Treatment Benefit of Cataract Surgery

Mihir Gandhi, Marcus Ang (), Kelvin Teo, Chee Wai Wong, Yvonne Chung-Hsi Wei, Rachel Lee-Yin Tan, Mathieu F. Janssen and Nan Luo
Additional contact information
Mihir Gandhi: Singapore Clinical Research Institute
Marcus Ang: Singapore National Eye Centre
Kelvin Teo: Singapore National Eye Centre
Chee Wai Wong: Singapore National Eye Centre
Yvonne Chung-Hsi Wei: Singapore National Eye Centre
Rachel Lee-Yin Tan: National University of Singapore
Mathieu F. Janssen: Erasmus MC
Nan Luo: National University of Singapore

The Patient: Patient-Centered Outcomes Research, 2019, vol. 12, issue 4, No 4, 383-392

Abstract: Abstract Background It is not clear whether 5-level EQ-5D (EQ-5D-5L) utilities based on recently developed value sets are more responsive than 3-level EQ-5D (EQ-5D-3L) utilities. Objectives The study aims were to compare (1) the responsiveness of EQ-5D-5L and EQ-5D-3L utilities and (2) the responsiveness of these utilities with the Short Form–6 Dimension (SF-6D) and Health Utilities Index Mark 3 (HUI3) utilities to the treatment benefit of cataract surgery. Methods A total of 148 patients were interviewed before and after their cataract surgery using EQ-5D-3L, EQ-5D-5L, SF-6D, and HUI3. Responsiveness was assessed for all measures using the mean change (post-treatment—pre-treatment), standardized effect size (SES), standardized response mean (SRM), and F-statistic. Results Using the Singapore value sets, mean change for EQ-5D-3L and EQ-5D-5L utilities was 0.016 and 0.028, SES was 0.097 and 0.199; SRM was 0.091 and 0.196; and F-statistic was 1.2 and 5.7, respectively. Similar trends were observed using the UK/England EQ-5D value sets, although the magnitude was slightly smaller. The mean change, SES, SRM and F-statistics for SF-6D (UK value set) were 0.020, 0.234, 0.249, and 9.2, respectively. The values of mean change, SES, SRM and F-statistics for HUI3 (Canada value set) were 0.080, 0.472, 0.474, and 33.3, respectively. Conclusions The EQ-5D-5L utilities tend to be more responsive than the EQ-5D-3L utilities to treatment benefits of cataract surgery. The HUI3 utilities are more responsive than both the EQ-5D-5L and SF-6D, and SF-6D utilities may be slightly more responsive than the EQ-5D-5L for assessing patients undergoing cataract surgery.

Date: 2019
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DOI: 10.1007/s40271-018-00354-7

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