Impact of Elagolix on Workplace and Household Productivity Among Women with Moderate to Severe Pain Associated with Endometriosis: A Pooled Analysis of Two Phase III Trials

Eric S. Surrey (), Ahmed M. Soliman, Hannah L. Palac and Sanjay K. Agarwal
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Eric S. Surrey: Colorado Center for Reproductive Medicine
Ahmed M. Soliman: AbbVie Inc.
Hannah L. Palac: AbbVie Inc.
Sanjay K. Agarwal: University of California

The Patient: Patient-Centered Outcomes Research, 2019, vol. 12, issue 6, No 10, 660 pages

Abstract: Abstract Background Endometriosis profoundly impairs women’s workplace and household productivity. Objective The aim of this study was to evaluate the impact of elagolix on endometriosis-related workplace and household productivity losses. Methods Data were pooled from two phase III trials of women aged 18–49 years with moderate to severe endometriosis-associated pain treated for 6 months with elagolix 150 mg daily (QD), 200 mg twice daily (BID), or placebo. The Health-Related Productivity Questionnaire was administered at baseline, Month 3, and Month 6 to determine workplace and household absenteeism and presenteeism. Productivity changes from baseline were compared between placebo and elagolix doses via analysis of covariance. Results Workplace analyses included 1270 employed women and household analyses included 1565 women. At baseline, women reported average weekly losses of 16 workplace hours, 8.3 household work hours, 45% of scheduled work, and 64% of planned household chores. At Month 6, treatment with elagolix 150 mg QD or 200 mg BID increased productive workplace hours by 1.7 (95% CI 0.1–3.4; p = 0.041) and 5.4 h (95% CI 3.7–7.1; p

Date: 2019
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DOI: 10.1007/s40271-019-00394-7

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