Using Patient Preferences in Health Technology Assessment: Evaluating Quality-Adjusted Survival Equivalents (QASE) for the Quantification of Non-health Benefits

Kevin Marsh (), Hannah Collacott, Jim Thomson, Jonathan Mauer, Stephen Watt, Koonal Shah, Brett Hauber, Louis Garrison and Mendwas Dzingina
Additional contact information
Kevin Marsh: Evidera
Hannah Collacott: Evidera
Jim Thomson: ViiV Healthcare
Jonathan Mauer: Pfizer
Stephen Watt: Pfizer
Koonal Shah: National Institute for Health and Care Excellence
Brett Hauber: Pfizer
Louis Garrison: University of Washington
Mendwas Dzingina: Pfizer

The Patient: Patient-Centered Outcomes Research, 2024, vol. 17, issue 3, No 3, 229-237

Abstract: Abstract Interest in using patient preference (PP) data alongside traditional economic models in health technology assessment (HTA) is growing, including using PP data to quantify non-health benefits. However, this is limited by a lack of standardised methods. In this article, we describe a method for using discrete choice experiment (DCE) data to estimate the value of non-health benefits in terms of quality-adjusted survival equivalence (QASE), which is consistent with the concept of value prevalent among HTA agencies. We describe how PP data can be used to estimate QASE, assess the ability to test the face-validity of QASE estimates of changes in mode of administration calculated from five published DCE oncology studies and review the methodological and normative considerations associated with using QASE to support HTA. We conclude that QASE may have some methodological advantages over alternative methods, but this requires DCEs to estimate second-order effects between length and quality of life. In addition, empirical work has yet to be undertaken to substantiate this advantage and demonstrate the validity of QASE. Further work is also required to align QASE with normative objectives of HTA agencies. Estimating QASE would also have implications for the conduct of DCEs, including standardising and defining more clear attribute definitions.

Date: 2024
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DOI: 10.1007/s40271-024-00676-9

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