Optimizing Communication on HPV Vaccination to Parents of 11- to 14-Year-Old Adolescents in France: A Discrete Choice Experiment

Sandra Chyderiotis, Jonathan Sicsic, Amandine Gagneux-Brunon, Jocelyn Raude, Anne-Sophie Barret, Sébastien Bruel, Aurélie Gauchet, Anne-Sophie Duc Banaszuk, Morgane Michel, Bruno Giraudeau, Nathalie Thilly and Judith E. Mueller ()
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Sandra Chyderiotis: Institut Pasteur, Université Paris Cité, Emerging Disease Epidemiology Unit
Jonathan Sicsic: Université Paris Cité, LIRAES
Amandine Gagneux-Brunon: CHU de Saint-Etienne-Service d’Infectiologie
Jocelyn Raude: Univ. Rennes, EHESP, CNRS, Inserm, Arènes-UMR 6051, RSMS (Recherche sur les Services et Management en Santé)-U1309
Anne-Sophie Barret: Santé Publique France
Sébastien Bruel: Saint-Etienne-Lyon University
Aurélie Gauchet: Université Savoie Mont Blanc, Univ. Grenoble Alpes, LIP/PC2S
Anne-Sophie Duc Banaszuk: Centre Régional de Coordination des Dépistages des cancers-Pays de la Loire
Morgane Michel: Université Paris Cité, ECEVE, UMR 1123, Inserm
Bruno Giraudeau: Université de Tours, Université de Nantes, INSERM, SPHERE U1246, INSERM CIC 1415, CHRU de Tours
Nathalie Thilly: Université de Lorraine, APEMAC
Judith E. Mueller: Institut Pasteur, Université Paris Cité, Emerging Disease Epidemiology Unit

The Patient: Patient-Centered Outcomes Research, 2024, vol. 17, issue 5, No 7, 575-588

Abstract: Abstract Background With the aim to optimize communication during HPV vaccination campaigns in France, we elicited parental preferences around HPV vaccination. Methods We conducted a single-profile discrete choice experiment (DCE) among parents of 11- to 14-year-old middle-school pupils, who completed an anonymous, self-administered, internet-based questionnaire during 2020–2021. The DCE comprised five attributes (vaccine-preventable disease, justification of optimal age, information on safety, indirect protection and coverage) of vaccination against an unnamed disease that were presented to respondents in ten choice tasks, or scenarios. We use fixed effect logit models to estimate attribute weights on theoretical vaccine acceptance, and random effect linear regression to estimate attribute coefficients on vaccine eagerness (decision and decision certainty). We estimated marginal effects of attributes on expected vaccine acceptance. Results Vaccination scenarios were accepted by 55.6–89.2% of the 1291 participants. The largest marginal effects on expected vaccine acceptance in the full sample arose from prevention of cancer versus genital warts (+ 11.3 percentage points); from a “severe side effect suspicion that was not scientifically confirmed” versus a statement about “more benefits than risks” (+ 8.9 percentage points), and information on 80% vaccine coverage in neighbouring countries versus on “insufficient coverage” (+ 4.2 percentage points). Explaining the early age of vaccination by sexual debut had a strong negative impact among French monolingual parents with lower education level (vs age-independent, OR 0.48, 95% CI 0.27–0.86), but not other socio-economic groups. After removing low-quality responses (unvaried certainty and short questionnaire completion), among serial non-demanders with children not vaccinated against HPV, only disease elimination impacted vaccine eagerness positively (coefficient 0.54, 0.06–1.02). Discussion Using DCEs to elicit parents’ preferences around communication messages, notably on cancer prevention, vaccine coverage and information about vaccine safety, could help to optimize HPV vaccination promotion efforts.

Date: 2024
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DOI: 10.1007/s40271-024-00687-6

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