Multi-part balanced incomplete-block designs

R. A. Bailey () and Peter J. Cameron
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R. A. Bailey: University of St Andrews
Peter J. Cameron: University of St Andrews

Statistical Papers, 2019, vol. 60, issue 2, No 5, 405-426

Abstract: Abstract We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some consequences. Then we give several different constructions. Finally we generalize this to three or more factors, such as biomarkers.

Keywords: Balanced incomplete-block design; Basket trial; Multi-part design; Orthogonal array; Orthogonal multi-array; 05B05; 05B15; 05B30; 62K10; 62K15 (search for similar items in EconPapers)
Date: 2019
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DOI: 10.1007/s00362-018-01071-x

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