Sperm penetration to the zona pellucida of an oocyte: a computational model incorporating acrosome reaction

Pavel Kozlovsky and Amit Gefen

Computer Methods in Biomechanics and Biomedical Engineering, 2013, vol. 16, issue 10, 1106-1111

Abstract: For fertilisation to occur, a spermatozoon needs to cross the zona pellucida (ZP), which is a glycoprotein layer surrounding the oocyte. Crossing the ZP requires an acrosome reaction (AR) where enzymes released from the spermatozoon head locally digest and soften the ZP so that the spermatozoon can penetrate deeper. Here, a biomechanical sperm–oocyte interaction model that considers the AR using the finite element method was formulated. This modelling is used to determine which of the following factors directly contribute to the crossing of the ZP: local ZP softening by AR, sperm head shape, ZP hardening elsewhere than in the AR site, ZP thickness and sperm hyperactivation (more flagellar beating). It has been found that an AR softening the ZP to over one-tenth of its basal stiffness is important for successful sperm penetration, and that ‘sharper’ heads have a biomechanical advantage in penetrating deeper. The approach is promising for understanding this exciting stage of reproduction.

Date: 2013
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://hdl.handle.net/10.1080/10255842.2013.768618 (text/html)
Access to full text is restricted to subscribers.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:taf:gcmbxx:v:16:y:2013:i:10:p:1106-1111

Ordering information: This journal article can be ordered from
http://www.tandfonline.com/pricing/journal/gcmb20

DOI: 10.1080/10255842.2013.768618

Access Statistics for this article

Computer Methods in Biomechanics and Biomedical Engineering is currently edited by Director of Biomaterials John Middleton

More articles in Computer Methods in Biomechanics and Biomedical Engineering from Taylor & Francis Journals
Bibliographic data for series maintained by Chris Longhurst ().