A two population model of prion transport through a tunnelling nanotube

I.A. Kuznetsov and A.V. Kuznetsov

Computer Methods in Biomechanics and Biomedical Engineering, 2014, vol. 17, issue 15, 1705-1715

Abstract: This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the TNT membrane and active actin-dependent transport inside endocytic vesicles that are propelled by myosin Va molecular motors. Analytical solutions describing prion concentrations and fluxes are obtained. Numerical results are compared with those predicted by a single prion population model that relies on a single reaction–diffusion equation and accounts for the two modes of prion transport in an effective way.

Date: 2014
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DOI: 10.1080/10255842.2013.763938

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