ADMET: ADipocyte METabolism mathematical model

Alessio Micheloni, Gianni Orsi, Carmelo De Maria and Giovanni Vozzi

Computer Methods in Biomechanics and Biomedical Engineering, 2015, vol. 18, issue 13, 1386-1391

Abstract: White fat cells have an important physiological role in maintaining triglyceride and free fatty acid levels due to their fundamental storage property, as well as determining insulin resistance. ADipocyte METabolism is a mathematical model that mimics the main metabolic pathways of human white fat cell, connecting inputs (composition of culture medium) to outputs (glycerol and free fatty acid release). It is based on a set of nonlinear differential equations, implemented in Simulink® and controlled by cellular energetic state. The validation of this model is based on a comparison between the simulation results and a set of experimental data collected from the literature.

Date: 2015
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DOI: 10.1080/10255842.2014.908855

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