 Mechanical evaluation of a tissue-engineered zone of calcification in a bone–hydrogel osteochondral constructJérôme Hollenstein, Alexandre Terrier, Esther Cory, Albert C. Chen, Robert L. Sah and Dominique P. Pioletti Computer Methods in Biomechanics and Biomedical Engineering, 2015, vol. 18, issue 3, 332-337 Abstract: The objective of this study was to test the hypothesis that mechanical properties of artificial osteochondral constructs can be improved by a tissue-engineered zone of calcification (teZCC) at the bone–hydrogel interface. Experimental push-off tests were performed on osteochondral constructs with or without a teZCC. In parallel, a numerical model of the osteochondral defect treatment was developed and validated against experimental results. Experimental results showed that the shear strength at the bone–hydrogel interface increased by 100% with the teZCC. Numerical predictions of the osteochondral defect treatment showed that the shear stress at the bone–hydrogel interface was reduced with the teZCC. We conclude that a teZCC in osteochondral constructs can provide two improvements. First, it increases the strength of the bone–hydrogel interface and second, it reduces the stress at this interface. Date: 2015 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:taf:gcmbxx:v:18:y:2015:i:3:p:332-337 Ordering information: This journal article can be ordered from DOI: 10.1080/10255842.2013.794898 Access Statistics for this article Computer Methods in Biomechanics and Biomedical Engineering is currently edited by Director of Biomaterials John Middleton More articles in Computer Methods in Biomechanics and Biomedical Engineering from Taylor & Francis Journals |
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