Computational study of cell adhesion and rolling in flow channel by meshfree method

Liqiang Lin and Xiaowei Zeng

Computer Methods in Biomechanics and Biomedical Engineering, 2017, vol. 20, issue 8, 832-841

Abstract: Tethering and rolling of circulating leukocytes on the surface of endothelium are critical steps during an inflammatory response. A soft solid cell model was proposed to study monocytes tethering and rolling behaviors on substrate surface in shear flow. The interactions between monocytes and micro-channel surface were modeled by a coarse-grained molecular adhesive potential. The computational model was implemented in a Lagrange-type meshfree Galerkin formulation to investigate the monocyte tethering and rolling process with different flow rates. From the simulation results, it was found that the flow rate has profound effects on the rolling velocity, contact area and effective stress of monocytes. As the flow rate increased, the rolling velocity would increase linearly, whereas the contact area and average effective stress in monocyte showed nonlinear increase.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
http://hdl.handle.net/10.1080/10255842.2017.1303051 (text/html)
Access to full text is restricted to subscribers.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:taf:gcmbxx:v:20:y:2017:i:8:p:832-841

Ordering information: This journal article can be ordered from
http://www.tandfonline.com/pricing/journal/gcmb20

DOI: 10.1080/10255842.2017.1303051

Access Statistics for this article

Computer Methods in Biomechanics and Biomedical Engineering is currently edited by Director of Biomaterials John Middleton

More articles in Computer Methods in Biomechanics and Biomedical Engineering from Taylor & Francis Journals
Bibliographic data for series maintained by Chris Longhurst ().