A global sensitivity analysis approach applied to a multiscale model of microvascular flow

L. Possenti, S. Di Gregorio, G. Casagrande, M. L. Costantino, T. Rancati and P. Zunino

Computer Methods in Biomechanics and Biomedical Engineering, 2020, vol. 23, issue 15, 1215-1224

Abstract: A global sensitivity analysis of a multiscale computational model of microvascular flow is presented. A total of 140 simulations have been completed and analyzed varying 6 input parameters and considering their effects on 7 output variables. Interestingly, the vascular network topology has been found as a determinant factor for both vasculature-related and interstitium-related quantities. Regarding the firsts, the vascular network topology has obtained a score of 5.5/6 and 6/6 for average and spatial distribution respectively (where 6 is the maximum and 1 is the minimum). On the other hand, considering interstitium-related quantities, the score is 4/6 and 5/6 for average and spatial distribution respectively. These results suggest that the network topology has a significant influence on the outcome of the computational analysis.

Date: 2020
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DOI: 10.1080/10255842.2020.1793964

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