Simulation study on the effect of resistance exercise on the hydrodynamic microenvironment of osteocytes in microgravity

Hai-Ying Liu, Chao-Hui Zhao, Hao Zhang, Wei Wang and Qing-Jian Liu

Computer Methods in Biomechanics and Biomedical Engineering, 2022, vol. 25, issue 15, 1757-1766

Abstract: Osteoporosis occurs in astronauts after long-term space flight owing to the lack of gravity. The mechanical microenvironment of osteocytes in load-bearing bone are changed during resistance exercise, which prevents massive bone loss in the human body. A cylindrical fluid-structure coupling finite element model for osteons with a two-stage pore structure (i.e., Haversian canal, lacunar-canalicular system) was established with the software COMSOL. In the Earth’s gravity field and in microgravity, considering the effects of pulsating pressure of arterioles, a comparative study was performed on the changes in hydrodynamic microenvironment of osteocytes during human body high-intensity exercise at different frequencies (defined as causing bone to produce 3000 με) and the body is at rest. Positive and negative liquid pressure (with respect to one atmosphere pressure) alternately acted on osteocytes during human exercising, but only positive pressure acted on osteocytes during human resting. The variation range of liquid pressure acted on osteocytes during human exercising was significantly higher than that during resting. The liquid flow velocity around osteocytes during body exercise was about four orders of magnitude higher than that during resting. In microgravity, moderate physical exercise can obviously improve the hydrodynamic microenvironment of osteocytes in load-bearing bone, which could compensate for the lack of mechanical stimulation to osteocytes caused by the lack of gravity, thereby promoting the normal physiological function of osteocytes. To a certain extent, these results revealed the biomechanical mechanism by which exercise has an effect in fighting osteoporosis in astronauts.HighlightsPositive and negative pressure alternately acted on osteocytes during exercise.Exercise obviously improve the fluid mechanics environment of osteocyte.Physical exercise has an effect in fighting osteoporosis in astronauts.Mechanical environment of osteocytes significantly depend on gravity fields.

Date: 2022
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DOI: 10.1080/10255842.2022.2037130

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