Numerical study of the effect of LVAD inflow cannula positioning on thrombosis risk

Ge He, Lu Han, Jiafeng Zhang, Aakash Shah, David J. Kaczorowski, Bartley P. Griffith and Zhongjun Wu

Computer Methods in Biomechanics and Biomedical Engineering, 2022, vol. 25, issue 8, 852-860

Abstract: Left ventricular assist devices (LVADs) have been increasingly used as a therapy for patients with end-stage heart failure. However, a growing number of clinical observations have shown that LVADs are associated with thromboembolic events, which are potentially related to the changes in intraventricular flow. Particularly, the flow fields around the inflow cannula (IC) of the LVAD. In this study, a fluid structure interaction (FSI) simulation was conducted to evaluate the hemodynamics of a patient specific left ventricle (LV) with varying LVAD IC orientations. The LV model was obtained from computed tomography scans and modeled to have contraction and relaxation during cardiac cycles following available experimental data of LV volume changes. The LV of the patient was assumed to have an end systolic volume of 223.7 mL and a stroke volume of 46.4 mL. Four different IC positions were considered: towards the (1) septum; (2) aortic valve (AV); (3) mitral valve (MV) and (4) inferior wall (IW). The potential thrombus growth around the IC was assumed to be caused by blood stagnation regions with low velocity (

Date: 2022
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DOI: 10.1080/10255842.2021.1984433

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