Computation of the mitochondrial age distribution along the axon length

Ivan A. Kuznetsov and Andrey V. Kuznetsov

Computer Methods in Biomechanics and Biomedical Engineering, 2023, vol. 26, issue 13, 1582-1594

Abstract: We describe a compartmental model of mitochondrial transport in axons, which we apply to compute mitochondrial age at different distances from the soma. The model predicts that at the tip of an axon that has a length of 1 cm, the average mitochondrial age is approximately 22 h. The mitochondria are youngest closest to the soma and their age scales approximately linearly with distance from the soma. To the best of the authors’ knowledge, this is the first attempt to predict the spatial distribution of mitochondrial age within an axon. A sensitivity study of the mean age of mitochondria to various model parameters is also presented.

Date: 2023
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DOI: 10.1080/10255842.2022.2128784

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