Biomechanical structure–function relations for human trabecular bone — comparison of calcaneus, femoral neck, greater trochanter, proximal tibia, and vertebra

Saghi Sadoughi, Grant Bevill, Elise F. Morgan, Vivek Palepu, Tony M. Keaveny and Keith A. Wear

Computer Methods in Biomechanics and Biomedical Engineering, 2023, vol. 26, issue 5, 508-516

Abstract: MicroCT-based finite element models were used to compute power law relations for uniaxial compressive yield stress versus bone volume fraction for 78 cores of human trabecular bone from five anatomic sites. The leading coefficient of the power law for calcaneus differed from those for most of the other sites (p 0.5) nor exponent (p > 0.5) differed among sites, suggesting that a given percentage deviation from mean bone volume fraction has the same mechanical consequence for all sites investigated. These findings help explain the success of calcaneal x-ray and ultrasound measurements for predicting hip fracture risk.

Date: 2023
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DOI: 10.1080/10255842.2022.2069465

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