On inlet pressure boundary conditions for CT-based computation of fractional flow reserve: clinical measurement of aortic pressure

Jincheng Liu, Suqin Huang, Xue Wang, Bao Li, Junling Ma, Yutong Sun, Jian Liu and Youjun Liu

Computer Methods in Biomechanics and Biomedical Engineering, 2023, vol. 26, issue 5, 517-526

Abstract: Background and objectivesA quick calculation approach of steady-state fractional flow reserve (FFRss) based on computed tomography angiography (CTA) images is a reliable non-invasive way of calculate FFR, the assumptions used in the research should be study further to increase forecast accuracy. The effect of inlet and outlet boundary conditions on FFRss was investigated.Methods15 patients who had been diagnosed with coronary artery disease were enrolled in this study. We investigated the sensitivity of calculating FFR to boundary circumstances, using invasive FFR as a benchmark. There are two types of inlet: (1) aortic pressure based on clinically measured. (2) mean pressure calculated based on physiological formula; we further studied the outlet changes of FFRss under different coronary vasodilation responses (24%, 48%, 72%).ResultsAccording to the calculate FFR results of all patients, FFRSST (based on the clinical experiment) and FFRSSM (based on the physiological formula) {r = 0.99, [95% confidence interval (CI):0.0.94 to 1.14] (p

Date: 2023
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DOI: 10.1080/10255842.2022.2072172

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