Development of a computational-experimental framework for enhanced mechanical characterization and cross-species comparison of the articular cartilage superficial zone

Steven P. Mell, Catherine Yuh, Thomas Nagel, Susan Chubinskaya, Hannah J. Lundberg and Markus A. Wimmer

Computer Methods in Biomechanics and Biomedical Engineering, 2024, vol. 27, issue 13, 1944-1948

Abstract: To provide a better understanding of the contribution of specific constituents (i.e. proteoglycan, collagen, fluid) to the mechanical behavior of the superficial zone of articular cartilage, a complex biological tissue with several time-dependent properties, a finite element model was developed. Optimization was then used to fit the model to microindentation experiments. We used this model to compare superficial zone material properties of mature human vs. immature bovine articular cartilage. Non-linearity and stiffness of the fiber-reinforced component of the model differed between human and bovine tissue. This may be due to the more complex collagen architecture in mature tissue and is of interest to investigate in future work.

Date: 2024
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DOI: 10.1080/10255842.2023.2255712

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