Design of three-section microneedle towards low insertion force and high drug delivery amount using the finite element method

Liqiang Zhang, Chenxi Zhu, Jiakang Shi, Zhuoran Zhou and Daohan Ge

Computer Methods in Biomechanics and Biomedical Engineering, 2024, vol. 27, issue 2, 156-166

Abstract: A microneedle has been greatly recognized as one of the most promising devices for novel transdermal drug delivery system due to its capacity of piercing the protective stratum corneum with a minimally invasive and painless manner. During the past two decades, although numerous achievements have been made in the structure and material combination of microneedles, they mostly focus on the pharmacology and functionality of microneedles, and little is reported about how to design the shape of microneedles to reduce insertion force and especially improve penetration efficiency. Using the developed finite element method, we designed three-section microneedles (TSMN) with various sizes and evaluated their maximum insertion force, penetration efficiency, drug delivery amount and strength. The simulation results demonstrate that the well-designed TSMN with shaft width of 60 μm exhibits a lower maximum insertion force of 116.68 mN relative to 167.92 mN of conical microneedle and an effective penetration length of 81.6% relative to 71.38% of conical microneedle. Besides, the optimized TSMN with shaft width of 80 μm shows similar maximum insertion force and 2.3 times the drug delivery amount compared to conical microneedle. These excellent properties are attributed to the optimized design of the shape curve of TSMN sidewall. Such results may provide an inspiration of microneedle design for low insertion force and high penetration efficiency.

Date: 2024
References: Add references at CitEc
Citations:

Downloads: (external link)
http://hdl.handle.net/10.1080/10255842.2023.2174019 (text/html)
Access to full text is restricted to subscribers.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:taf:gcmbxx:v:27:y:2024:i:2:p:156-166

Ordering information: This journal article can be ordered from
http://www.tandfonline.com/pricing/journal/gcmb20

DOI: 10.1080/10255842.2023.2174019

Access Statistics for this article

Computer Methods in Biomechanics and Biomedical Engineering is currently edited by Director of Biomaterials John Middleton

More articles in Computer Methods in Biomechanics and Biomedical Engineering from Taylor & Francis Journals
Bibliographic data for series maintained by Chris Longhurst ().