Exploring the influence of parametrized pulsatility on left ventricular washout under LVAD support: a computational study using reduced-order models

M. R. Schuster, N. Dirkes, F. Key, S. Elgeti and M. Behr

Computer Methods in Biomechanics and Biomedical Engineering, 2025, vol. 28, issue 6, 800-817

Abstract: Introducing pulsatility in LVADs is known to reduce complications such as stagnation and thrombosis, but it is an ongoing topic of research on what the optimal form is. We present a framework consisting of parametrized full-order simulations, reduced-order models, and sensitivity analysis to systematically quantify the effects of parametrized pulsatility on washout. As a sample problem, we study the washout in an idealized 2D left ventricle and a parametrized sinusoidal LVAD flow rate. The framework yields speed-ups proportional to the number of samples required in the sensitivity analysis. In our setting, we find that short, intense pulses wash out the left ventricle best, while the time between consecutive pulses does not play a significant role.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
http://hdl.handle.net/10.1080/10255842.2024.2320747 (text/html)
Access to full text is restricted to subscribers.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:taf:gcmbxx:v:28:y:2025:i:6:p:800-817

Ordering information: This journal article can be ordered from
http://www.tandfonline.com/pricing/journal/gcmb20

DOI: 10.1080/10255842.2024.2320747

Access Statistics for this article

Computer Methods in Biomechanics and Biomedical Engineering is currently edited by Director of Biomaterials John Middleton

More articles in Computer Methods in Biomechanics and Biomedical Engineering from Taylor & Francis Journals
Bibliographic data for series maintained by Chris Longhurst ().