Interval estimation of the 90% effective dose: A comparison of bootstrap resampling methods with some large-sample approaches

Yangxin Huang Simon, P. J. Kirby Peter, Harris John and C. Dearden

Journal of Applied Statistics, 2000, vol. 27, issue 1, 63-73

Abstract: A number of recent studies have looked at the coverage probabilities of various common parametric methods of interval estimation of the median effective dose (ED 50 ) for a logistic dose-response curve. There has been comparatively little work done on more extreme effective doses. In this paper, the interval estimation of the 90% effective dose (ED 90 ) will be of principal interest. We provide a comparison of four parametric methods of interval construction with four methods based on bootstrap resampling.

Date: 2000
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DOI: 10.1080/02664760021835

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