Robustness of interval estimation of the 90% effective dose: Bootstrap resampling and some large-sample parametric methods

Yangxin Huang

Journal of Applied Statistics, 2002, vol. 29, issue 7, 1071-1081

Abstract: Interval estimation of the x th effective dose (ED x ), where x is a prespecified percentage, has been the focus of interest of a number of recent studies, the majority of which have considered the case in which a logistic dose-response curve is correctly assumed. In this paper, we focus our attention upon the 90% effective dose (ED 90 ) and consider the situation in which the assumption of a logistic dose-response curve is incorrect. Specifically, we consider three classes of true model: the probit, the cubic logistic and the asymmetric Aranda-Ordaz models. We investigate the robustness of four large sample parametric methods of interval construction and four methods based upon bootstrap resampling.

Date: 2002
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DOI: 10.1080/0266476022000006748

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