Accounting for plasma levels below detection limits in a one-compartment zero-order absorption pharmacokinetics model

Alan Hutson, Lauren Fishbein, Patricia O'Brien and Peter Stacpoole

Journal of Applied Statistics, 2002, vol. 29, issue 8, 1181-1190

Abstract: We provide a simple method for fitting a one-compartment, zero-order absorption pharmacokinetics model in the presence of observations below the detection limit. This method may be extended to more complex pharmacokinetics models. We demonstrate, using a small simulation study, that the method provides accurate parameter estimates over a range of detection limits and we compare it to an ad hoc midpoint method. An applied example is provided from a pharmacokinetic investigation of a nicotine nasal spray.

Date: 2002
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DOI: 10.1080/0266476022000011256

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