A permutation test approach to phase II historical control trials

Alan Hutson, Maurie Markman and Mark Brady

Journal of Applied Statistics, 2009, vol. 36, issue 6, 589-599

Abstract: In this note we outline 15 years of Gynecologic Oncology Group (GOG) experience conducting a series of phase II second-line intraperitoneal trials in the treatment of ovarian cancer. Using this information, the goal is to define a new permutation approach to historical control phase II trials in ovarian cancer. We utilize seven previous phase II GOG trials in our database to illustrate our methodology.

Keywords: clinical trial; non-randomized (search for similar items in EconPapers)
Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:taf:japsta:v:36:y:2009:i:6:p:589-599

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DOI: 10.1080/02664760802474280

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