 Analysis of microtubule dynamics using growth curve modelsS. Rao Jammalamadaka, Md. Aleemuddin Siddiqi and Kaushik Ghosh Journal of Applied Statistics, 2009, vol. 36, issue 6, 621-631 Abstract: Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics. Keywords: growth curves; microtubule dynamics; polynomial regression; splines; MANOVA; Wilks' Lamda (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:taf:japsta:v:36:y:2009:i:6:p:621-631 Ordering information: This journal article can be ordered from DOI: 10.1080/02664760802479131 Access Statistics for this article Journal of Applied Statistics is currently edited by Robert Aykroyd More articles in Journal of Applied Statistics from Taylor & Francis Journals |
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