Mixtures of concentrated multivariate sine distributions with applications to bioinformatics

Kanti V. Mardia, John T. Kent, Zhengzheng Zhang, Charles C. Taylor and Thomas Hamelryck

Journal of Applied Statistics, 2012, vol. 39, issue 11, 2475-2492

Abstract: Motivated by examples in protein bioinformatics, we study a mixture model of multivariate angular distributions. The distribution treated here (multivariate sine distribution) is a multivariate extension of the well-known von Mises distribution on the circle. The density of the sine distribution has an intractable normalizing constant and here we propose to replace it in the concentrated case by a simple approximation. We study the EM algorithm for this distribution and apply it to a practical example from protein bioinformatics.

Date: 2012
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Citations: View citations in EconPapers (2)

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DOI: 10.1080/02664763.2012.719221

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