Generalizing the standardized hazard ratio to multivariate proportional hazards regression, with an application to clinical~genomic studies

Michael R. Crager

Journal of Applied Statistics, 2012, vol. 39, issue 2, 399-417

Abstract: The standardized hazard ratio for univariate proportional hazards regression is generalized as a scalar to multivariate proportional hazards regression. Estimators of the standardized log hazard ratio are developed, with corrections for bias and for regression to the mean in high-dimensional analyses. Tests of point and interval null hypotheses and confidence intervals are constructed. Cohort sampling study designs, commonly used in prospective--retrospective clinical genomic studies, are accommodated.

Date: 2012
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DOI: 10.1080/02664763.2011.594034

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