 Large-Scale Multiple Testing of CorrelationsT. Tony Cai and Weidong Liu Journal of the American Statistical Association, 2016, vol. 111, issue 513, 229-240 Abstract: Multiple testing of correlations arises in many applications including gene coexpression network analysis and brain connectivity analysis. In this article, we consider large-scale simultaneous testing for correlations in both the one-sample and two-sample settings. New multiple testing procedures are proposed and a bootstrap method is introduced for estimating the proportion of the nulls falsely rejected among all the true nulls. We investigate the properties of the proposed procedures both theoretically and numerically. It is shown that the procedures asymptotically control the overall false discovery rate and false discovery proportion at the nominal level. Simulation results show that the methods perform well numerically in terms of both the size and power of the test and it significantly outperforms two alternative methods. The two-sample procedure is also illustrated by an analysis of a prostate cancer dataset for the detection of changes in coexpression patterns between gene expression levels. Supplementary materials for this article are available online. Date: 2016 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:taf:jnlasa:v:111:y:2016:i:513:p:229-240 Ordering information: This journal article can be ordered from DOI: 10.1080/01621459.2014.999157 Access Statistics for this article Journal of the American Statistical Association is currently edited by Xuming He, Jun Liu, Joseph Ibrahim and Alyson Wilson More articles in Journal of the American Statistical Association from Taylor & Francis Journals |
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