Randomization Inference and Sensitivity Analysis for Composite Null Hypotheses With Binary Outcomes in Matched Observational Studies

Colin B. Fogarty, Pixu Shi, Mark E. Mikkelsen and Dylan S. Small

Journal of the American Statistical Association, 2017, vol. 112, issue 517, 321-331

Abstract: We present methods for conducting hypothesis testing and sensitivity analyses for composite null hypotheses in matched observational studies when outcomes are binary. Causal estimands discussed include the causal risk difference, causal risk ratio, and the effect ratio. We show that inference under the assumption of no unmeasured confounding can be performed by solving an integer linear program, while inference allowing for unmeasured confounding of a given strength requires solving an integer quadratic program. Through simulation studies and data examples, we demonstrate that our formulation allows these problems to be solved in an expedient manner even for large datasets and for large strata. We further exhibit that through our formulation, one can assess the impact of various assumptions about the potential outcomes on the performed inference. R scripts are provided that implement our methods. Supplementary materials for this article are available online.

Date: 2017
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DOI: 10.1080/01621459.2016.1138865

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