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Am I dependent on a lifetime use of antipsychotics? A qualitative analysis of Q&A data about stopping and tapering antipsychotics from the perspective of users and their relatives

S. Crutzen, J. van Os and S. Castelein

Psychosis, 2025, vol. 17, issue 3, 264-275

Abstract: BackgroundMany antipsychotic users at some point want to stop their antipsychotic. They mention side effects, functioning, experiencing no benefits and health concerns as motivations. The aim was to explore questions antipsychotic users and their relatives have about stopping or tapering antipsychotics.MethodsData were used from a publicly available anonymous expert Q&A in which experts answered questions about mental health. Questions about stopping or tapering antipsychotics asked by antipsychotics users and their relatives were analysed using an inductive content analysis.ResultsA total of 3000 questions were screened, where 426 were about antipsychotics and 194 were about stopping or tapering antipsychotics. The most common question was whether it was sensible to stop. Questions focused on how fast to taper, what their minimum dose should be, where to find support and when withdrawal symptoms or side effects would subside. Motivations were side effects, difficulties in functioning and experiencing no benefits. Barriers were lack of support and return of symptoms. Facilitators were support and experiencing a relief from side effects and/or symptoms.DiscussionAntipsychotic users and their relatives are left with many questions about tapering antipsychotics. These questions reveal attitudes, preferences and concerns that are important to address when discussing antipsychotic treatment.

Date: 2025
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DOI: 10.1080/17522439.2024.2430466

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