Simon's minimax and optimal and Jung's admissible two-stage designs with or without curtailment

Cornelia U. Kunz () and Meinhard Kieser
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Cornelia U. Kunz: University of Heidelberg, Germany
Meinhard Kieser: University of Heidelberg, Germany

Stata Journal, 2011, vol. 11, issue 2, 240-254

Abstract: This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials. Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1–10) and admissible designs described by Jung et al. (2004, Statistics in Medicine 23: 561–569). Furthermore, nonstochastic and stochastic curtailment rules can be im- plemented in both stages of the trial, and the properties of the curtailed designs can be examined. Copyright 2011 by StataCorp LP.

Keywords: simontwostage; Simon's two-stage design; Jung's admissible design; phase II trials; conditional power; curtailment (search for similar items in EconPapers)
Date: 2011
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