Tools to simulate realistic censored survival-time distributions

Patrick Royston ()
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Patrick Royston: MRC Clinical Trials Unit

Stata Journal, 2012, vol. 12, issue 4, 639-654

Abstract: Simulation of realistic censored survival times is challenging. Most research studies use highly simplified models, such as the exponential, that do not adequately reflect the patterns of time to event and censoring seen in real datasets. In this article, I present a general method of simulating such data based on flexible parametric survival models (Royston and Parmar, 2002, Statistics in Medicine 21: 2175–2197). A key component of the approach is modeling not only the time to event but also the time to censoring. I illustrate the methods in data from clinical trials and from a prognostic study. I also describe http://www.stata-journal.com/software/a new Stata program, stsurvsim, that does the necessary calculations. Copyright 2012 by StataCorp LP.

Keywords: stsurvsim; survival analysis; Monte Carlo simulation; flexible parametric survival models; time to event; time to censoring; clinical trials (search for similar items in EconPapers)
Date: 2012
Note: to access software from within Stata, net describe http://www.stata-journal.com/software/sj12-4/st0274/
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