Trial sequential boundaries for cumulative meta-analyses

Branko Miladinovic (), Iztok Hozo and Benjamin Djulbegovic
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Branko Miladinovic: University of South Florida
Iztok Hozo: Indiana University Northwest
Benjamin Djulbegovic: University of South Florida

Stata Journal, 2013, vol. 13, issue 1, 77-91

Abstract: We present a new command, metacumbounds, for the estimation of trial sequential monitoring boundaries in cumulative meta-analyses. The approach is based on the Lan–DeMets method for estimating group sequential boundaries in individual randomized controlled trials by using the package ldbounds in R statistical software. Through Stata’s metan command, metacumbounds plots the Lan–DeMets bounds, z-values, and p-values obtained from both fixed and randomeffects cumulative meta-analyses. The analysis can be performed with count data or on the hazard scale for time-to-event data. Copyright 2013 by StataCorp LP.

Keywords: metacumbounds; trial sequential analysis; cumulative metaanalysis; information size; Lan–DeMets bounds; monitoring boundary; cumulative z score; heterogeneity (search for similar items in EconPapers)
Date: 2013
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